The Wangaya Regional General Hospital, Denpasar City, was founded in 1921 with 30 beds, 15 for sick Europeans and Chinese and 15 other beds for native people.

Wangaya Regional General Hospital, Denpasar City is the health service center for South Bali, while for North Bali the health service activity is Singaraja Hospital.

If we divide the time period regarding the development of health services at the Wangaya Regional General Hospital, Denpasar City, it can be categorized as follows:

1. Colonial Period of the Dutch East Indies Government (1921 – 1942)

At this time Wangaya General Hospital also provided services for leprosy and infectious diseases. The doctors who provided services were Dutch doctors, Javanese doctors assisted by ZEIKEN OPASSER (Guardian of the Sick), I Wayan Nugra was the most diligent and active Zeiken Opasser at that time. During this period there were several changes in Director, in 1921 it was Doctor Abdul Tahir, in 1923 it was Doctor Wirasma, in 1936 it was Doctor Benne and in 1937 it was Doctor Eykman.

2. Japanese Colonization Period (1942 – 1945)

With the fall of the Netherlands and the coming to power of Japan, the General Hospital automatically came under Japanese Government.

During this period, health services declined greatly because all the doctors and health workers from the Netherlands and Europe were captured by the Japanese, medicines and health facilities were very limited so that the level of public health was very low.

3. The period of the Physical Revolution up to the unification of the RIS into the Unitary State of the Republic of Indonesia (1945 – 1951)

At this time, Wangaya Hospital, especially its nurses, helped many of the fighters at that time, including Made Suberata, I Gde Pelasa, Ida Bagus Kompiang, I Nyoman Purna, I Made Rasna, Ida Bagus Jagra, I Made Putra, I Gusti Putu Susesa. Apart from helping many fighters, Wangaya Hospital at this time played a very important role in producing nursing staff by opening nursing education.

4. The period when the island of Bali was part of the Lesser Sunda Province / Nusa Tenggara until Bali stood as a Province until now.

During this time, health services began to develop well, due to the beginning of the separation of Bali as part of the Lesser Sunda province. In March 1963, when Mount Agung erupted, the dedication of the nursing staff at Wangaya Hospital was very great, where Ida Bagus Kompiang was the leader and organized the nursing staff to serve as volunteers to help victims of the volcanic eruption.

During the period 1921 – 2007 the Wangaya Regional General Hospital was led by 28 Directors. With the formation of the Denpasar City Government in 1992, the Wangaya Denpasar Hospital was under the auspices of the Denpasar City Government and with the Decree of the Mayor of Denpasar City Number 96 of 2008 concerning the Determination of the Denpasar City Wangaya Regional General Hospital Service Agency as a Regional Public Service Agency.